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Marching further along the path for planned inability to reproduce viable humans?

Howard Hughes Medical team finds a new way of editing mtDNA (mitochondrial DNA – crucial to life, passed by the mother) via bacterial toxin vs CRSPR.

New Precision Gene Editing Tool for mtDNA Developed
A team of Howard Hughes Medical Institute (HHMI) scientists said they have developed, to their knowledge, the first precision gene editing tool for mitochondrial DNA (mtDNA). The CRISPR-free technology, which applies an interbacterial toxin, is designed to facilitate the study of mitochondrial diseases and basic mitochondrial biology in animals. HHMI investigator David Liu, PhD, of Harvard University and the Broad Institute of MIT and Harvard partnered with HHMI colleagues Joseph Mougous, PhD, at the University of Washington, and Vamsi Mootha, PhD, at Massachusetts General Hospital and the Broad. Liu’s team, led by graduate student Beverly Mok, relied on 3D imaging data from the Mougous lab to divide a deaminase into two pieces. The team fused each deaminase half to customizable DNA-targeting proteins that did not require guide RNAs. The proteins bound to specific stretches of DNA, bringing the two halves together. That let the deaminase regain function and work as a precision gene editor, once correctly positioned. The researchers detailed their discovery in a paper published in Nature.
https://www.nature.com/articles/s41586-020-2477-4